Premium
Nanocarrier Stimuli‐Activated Gene Delivery
Author(s) -
Howard Kenneth A.,
Dong Mingdong,
Oupicky David,
Bisht Harender S.,
Buss Claus,
Besenbacher Flemming,
Kjems Jørgen
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200600328
Subject(s) - nanocarriers , nanotechnology , drug delivery , gene delivery , materials science , intracellular , gene , chemistry , transfection , biochemistry
Gene genie: Stimuli‐activated changes in gene‐delivery systems are investigated using AFM. Thermoresponsive nanocarriers (see image) show size increases over a scale range that can be exploited for site‐specific deposition. Redox‐responsive nanocarriers in intracellular environment conditions disassemble into the component parts. These findings highlight the importance of research at the pharmaceutical–nanotechnology interface in the development of next‐generation drug‐delivery systems.