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A Macrophage‐Targeted Theranostic Nanoparticle for Biomedical Applications
Author(s) -
McCarthy Jason R.,
Jaffer Farouc A.,
Weissleder Ralph
Publication year - 2006
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200600139
Subject(s) - biocompatible material , macrophage , phototoxicity , photodynamic therapy , nanoparticle , avidity , magnetic nanoparticles , nanotechnology , materials science , medicine , chemistry , biomedical engineering , immunology , biochemistry , organic chemistry , antibody , in vitro
Diagnosis and therapy in one : Many prevalent diseases, such as atherosclerosis, could be efficiently treated by localized, macrophage‐targeted therapies. A biocompatible nanoparticle with high macrophage avidity is presented; the nanoparticle has magnetic and fluorescence, as well as therapeutic, imaging functionalities. Multimodal detection and exquisite phototoxicity to macrophages under appropriate illumination is shown (see image).