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Gold‐Conjugated Protein Nanoarrays through Block‐Copolymer Lithography: From Fabrication to Biosensor Design
Author(s) -
Jung JinMi,
Kwon Ki Young,
Ha TaiHwan,
Chung Bong Hyun,
Jung HeeTae
Publication year - 2006
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200600005
Subject(s) - copolymer , biosensor , lithography , nanotechnology , template , fabrication , conjugated system , materials science , block (permutation group theory) , computer science , polymer , optoelectronics , medicine , alternative medicine , pathology , composite material , geometry , mathematics
A hole lot of protein : A method to immobilize proteins at defined positions at the single‐molecule level has been developed by using templates structured by block‐copolymer lithography to generate ultrahigh‐density protein nanoarrays (see image). Carbohydrate–lectin (RCA or WGA) interactions on the nanoarray surface have remarkably high selectivity and reproducibility and indicate that this approach is applicable for biosensors.