Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity | Zendy

Aryal Baikuntha P. | Zendy; Neupane Kosh P. | Zendy; Sandros Marinella G. | Zendy; Benson David E. | Zendy

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Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity

Author(s) -

Aryal Baikuntha P.,

Neupane Kosh P.,

Sandros Marinella G.,

Benson David E.

Publication year - 2006

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.200500527

Subject(s) - nanoparticle , toxicity , nanotoxicology , cysteine , nanotechnology , chemistry , metallothionein , materials science , biophysics , biochemistry , zinc , enzyme , biology , organic chemistry

The toxicity of CdSe nanoparticles is mediated by metallothioneins (MTs), which are ubiquitous and cysteine‐rich. Surface Cd 2+ ions are depleted from thiocarboxylate‐capped CdSe nanoparticles by recombinant MT‐based peptides (see figure), while surface Zn 2+ ion depletion from ZnS‐coated CdSe nanoparticles is more difficult. Due to the overall cellular expression and antioxidant roles for MT, a model for MT‐mediated CdSe nanoparticle toxicity is proposed.

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