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Controlled Ligand Display on a Symmetrical Protein‐Cage Architecture Through Mixed Assembly
Author(s) -
Gillitzer Eric,
Suci Peter,
Young Mark,
Douglas Trevor
Publication year - 2006
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200500433
Subject(s) - cage , architecture , nanotechnology , ligand (biochemistry) , computer science , materials science , crystallography , chemistry , engineering , geography , structural engineering , biochemistry , receptor , archaeology
Do you feel caged in? The surface of protein‐cage structures can effectively be covered with a controlled density of different ligands (see picture). In vitro reassembly of independently modified cage subunits mixed at varying molar ratios generates particles with a defined mean number of a functional ligand attached to the surface of the protein cage.
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