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Specific Targeting, Cell Sorting, and Bioimaging with Smart Magnetic Silica Core–Shell Nanomaterials
Author(s) -
Yoon TaeJong,
Yu Kyeong Nam,
Kim Eunha,
Kim Jun Sung,
Kim Byung Geol,
Yun SangHyun,
Sohn ByeongHyeok,
Cho MyungHaing,
Lee JinKyu,
Park Seung Bum
Publication year - 2006
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200500360
Subject(s) - nanomaterials , surface modification , covalent bond , nanotechnology , maleimide , materials science , magnetic nanoparticles , nanoparticle , peg ratio , magnetic core , membrane , chemistry , polymer chemistry , organic chemistry , biochemistry , finance , engineering , electrical engineering , economics , electromagnetic coil
Organic dye‐incorporated smart silica‐coated core–shell magnetic nanoparticles (MNP@SiO 2 ) having dual‐functionality (‐PEG/NH 2 , see Figure) were easily fabricated, and the amine moieties on the NP surface were modified with maleimide functionality for specific covalent immobilization of biopolymers and bioactive small molecules. The sequence‐independent immobilization of antibodies (Ab) is highlighted; Ab‐modified MNP@SiO 2 particles exhibit specific recognition for floating tumor cells or target the membrane of adherent breast cancer cells.