Selective Loading of Kinesin‐Powered Molecular Shuttles with Protein Cargo and its Application to Biosensing | Zendy

Ramachandran Sujatha | Zendy; Ernst KarlHeinz | Zendy; Bachand George D. | Zendy; Vogel Viola | Zendy; Hess Henry | Zendy

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Selective Loading of Kinesin‐Powered Molecular Shuttles with Protein Cargo and its Application to Biosensing

Author(s) -

Ramachandran Sujatha,

Ernst KarlHeinz,

Bachand George D.,

Vogel Viola,

Hess Henry

Publication year - 2006

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.200500265

Subject(s) - kinesin , biotinylation , streptavidin , microtubule , molecular motor , motor protein , protein filament , nanotechnology , chemistry , biophysics , microbiology and biotechnology , materials science , biotin , biochemistry , biology

A new shuttle mission : The design of molecular shuttles, which integrate the motor protein kinesin to propel microtubules (the associated polymeric filament), requires a general strategy to achieve selective cargo binding. We describe the in situ functionalization of biotinylated microtubules with biotinylated antibodies via a streptavidin bridge and demonstrate that selective binding of antigens can be detected via a double‐antibody sandwich assay on the moving shuttle.

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