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A Magnetically Separable, Highly Stable Enzyme System Based on Nanocomposites of Enzymes and Magnetic Nanoparticles Shipped in Hierarchically Ordered, Mesocellular, Mesoporous Silica
Author(s) -
Kim Jungbae,
Lee Jinwoo,
Na Hyon Bin,
Kim Byoung Chan,
Youn Jong Kyu,
Kwak Ja Hun,
Moon Karam,
Lee Eunwoong,
Kim Jaeyun,
Park Jongnam,
Dohnalkova Alice,
Park Hyun Gyu,
Gu Man Bock,
Chang Ho Nam,
Grate Jay W.,
Hyeon Taeghwan
Publication year - 2005
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200500245
Subject(s) - lipase , nanocomposite , mesoporous silica , nanoparticle , glutaraldehyde , magnetic nanoparticles , adsorption , enzyme , materials science , nanotechnology , chemical engineering , mesoporous material , chemistry , organic chemistry , catalysis , engineering
Multifunctional nanocomposites (M‐CLEAs) of enzymes and magnetic nanoparticles (M‐NPs) were fabricated in hierarchically ordered, mesocellular, mesoporous silica (HMMS; see Figure) by a simple process involving the co‐adsorption of enzyme molecules and magnetic nanoparticles into HMMS followed by glutaraldehyde (GA) treatment. These nanocomposites are magnetically separable and highly stable and active. In particular, M‐CLEA–lipase shows no decrease of lipase activity at all in the presence of proteases.