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Cellular Uptake and Toxicity of Au 55 Clusters
Author(s) -
Tsoli Maria,
Kuhn Hubert,
Brandau Wolfgang,
Esche Helmut,
Schmid Günter
Publication year - 2005
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200500104
Subject(s) - toxicity , colloidal gold , nanotechnology , nanoparticle , contrast (vision) , dna , chemistry , materials science , computer science , biochemistry , artificial intelligence , organic chemistry
Gold clusters (Au 55 ) have been shown to interact with DNA (see image). Armed with this knowledge, experiments have shown that such clusters are shown to have significant toxicity towards many types of human cells, both healthy and cancerous, in contrast to previously studied larger gold nanoparticles. It is hoped, therefore, that there is a future for Au 55 clusters in the treatment of certain cancers.