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Flow Focusing: A Versatile Technology to Produce Size‐Controlled and Specific‐Morphology Microparticles
Author(s) -
MartínBanderas Lucía,
FloresMosquera María,
RiescoChueca Pascual,
RodríguezGil Alfonso,
Cebolla Ángel,
Chávez Sebastián,
GañánCalvo Alfonso M.
Publication year - 2005
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200500087
Subject(s) - nanotechnology , flow focusing , materials science , nanoparticle , multiplexing , drug delivery , microfluidics , computer science , telecommunications
The Flow Focusing platform is especially advantageous for micro‐ and nanoparticle production. This versatile technique is amenable to designing the size, surface treatment and internal topology of the particles; mechanical stresses are minimal—an optimal feature for the manipulation of delicate substances. Multiplexing and high‐rate production are readily implemented. Adaptive operational design can lead, in one single step, to finely tuned microcapsules encasing different products within a targeted morphology. This achievement is of great significance for most microcapsule applications in the biosciences (for example, drug delivery, cell encapsulation, and the production of bead arrays).