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An Engineered Virus as a Scaffold for Three‐Dimensional Self‐Assembly on the Nanoscale
Author(s) -
Blum Amy Szuchmacher,
Soto Carissa M.,
Wilson Charmaine D.,
Brower Tina L.,
Pollack Steven K.,
Schull Terence L.,
Chatterji Anju,
Lin Tianwei,
Johnson John E.,
Amsinck Christian,
Franzon Paul,
Shashidhar Ranganathan,
Ratna Banahalli R.
Publication year - 2005
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200500021
Subject(s) - scaffold , nanotechnology , nanoscopic scale , capsid , nanoparticle , scaffold protein , materials science , self assembly , conjugated system , virus , chemistry , computer science , polymer , biology , biochemistry , virology , signal transduction , database , composite material
Exquisite control over positioning nanoscale components on a protein scaffold allows bottom‐up self‐assembly of nanodevices. Using cowpea mosaic virus, modified to express cysteine residues on the capsid exterior, gold nanoparticles were attached to the viral scaffold to produce specific interparticle distances (see picture). The nanoparticles were then interconnected using thiol‐terminated conjugated organic molecules that act as “molecular wires”, resulting in a 3D spherical conductive network, which is only 30 nm in diameter.