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Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
Author(s) -
Connor Ellen E.,
Mwamuka Judith,
Gole Anand,
Murphy Catherine J.,
Wyatt Michael D.
Publication year - 2005
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200400093
Subject(s) - cytotoxicity , nanoparticle , nanotechnology , colloidal gold , materials science , chemistry , in vitro , biochemistry
A series of gold nanoparticles were examined for uptake and acute toxicity in human leukemia cells. The nanoparticles (average diameter=18 nm), which possessed various surface modifiers, were not toxic to cells during continuous exposure for three days. Citrate‐capped nanoparticles were further examined for their cellular uptake by absorbance and transmission electron microscopy (see image). Results indicate that although some precursors of nanoparticles may be toxic, the nanoparticles themselves are not necessarily detrimental to cellular function.