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Inhibition is associated with metabolic syndrome and depression through inflammation
Author(s) -
Murdock Kyle W.,
LeRoy Angie S.,
Fagundes Christopher P.
Publication year - 2018
Publication title -
stress and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 61
eISSN - 1532-2998
pISSN - 1532-3005
DOI - 10.1002/smi.2808
Subject(s) - depression (economics) , mechanism (biology) , inflammation , psychology , metabolic syndrome , behavioral inhibition , neuropsychology , response inhibition , clinical psychology , cognition , medicine , psychiatry , anxiety , obesity , philosophy , epistemology , economics , macroeconomics
Inhibition is the ability to stop one's self from responding, or paying attention, to tempting/distracting stimuli or thoughts. Those with poor inhibition are at greater risk of depression and a variety of diseases of older adulthood than those with better inhibition. Inflammation may be a mechanism underlying these links. A total of 840 participants from the Midlife in the United States study completed a neuropsychological measure of inhibition, a self‐report measure of depressive symptoms, and a blood draw. Results indicated that poor inhibition was associated with high interleukin‐6 (IL‐6). Inhibition was indirectly associated with metabolic syndrome incidence and depressive symptoms through IL‐6. Findings suggest that IL‐6 may be a mechanism linking inhibition with metabolic syndrome and depression.