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Histopathologic changes in rat kidneys exposed to acute and chronic immobilization stress
Author(s) -
Vesna Stojanovic,
Nada Vuckovic,
Nenad Barisic,
Aleksandra Doronjski
Publication year - 2011
Publication title -
stress and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 61
eISSN - 1532-2998
pISSN - 1532-3005
DOI - 10.1002/smi.1362
Subject(s) - chronic stress , edema , medicine , pathology
Aim of this study was to detect and quantify histological changes in kidneys after exposure to acute and chronic stress. Rats were divided into the groups consisting of 12 animals: control group—freely moving (unstressed); rats subjected to immobilization for 2 h; rats subjected to repeated 2 h immobilization for ten consecutive days; rats subjected to repeated 2 h immobilization for two consecutive days. Eight features of histopathological damage were scored on normal (0) to severe (4) scale. Changes occured in the kidneys during both, acute and chronic stress. The most common type of degeneration is ‘cloudy swelling’ in epithelial cells of proximal and distal tubules and interstitial edema. Chronic stress induces more prominent changes, which inflict more glomeruls than acute stress. Acute and repetitive stress induces mild or moderate histopathologic changes in kidneys. Copyright © 2010 John Wiley & Sons, Ltd.