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Acetic Acid Mediated Electrochemical Synthesis of Benzazole and its Application in the Synthesis of Pharmaceutically Active Compounds
Author(s) -
Ghoshal Tanay,
Patel Tarun M.,
Kotturi Sharadsrikar
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202102587
Subject(s) - acetic acid , electrochemistry , chemistry , yield (engineering) , electrolyte , methanol , substrate (aquarium) , combinatorial chemistry , supporting electrolyte , solubility , organic chemistry , electrode , materials science , oceanography , metallurgy , geology
An acetic acid promoted electrochemical synthesis of benzazoles, benzimidazoles, benzthiazoles and benzoxazoles, is reported. The method offers large substrate scope, good functional group tolerance, while using cheap electrolyte. The method uses acetic acid as the electrolyte which has a better solubility in methanol, hence the reaction time is less and product formation is observed in high yield without much side product. This electrochemical method is further utilised to synthesise thiabendazole, fuberidazole, chlormidazole and advance intermediates of bilastine and clemizole in good yields.