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Enantioselective Total Synthesis of Sacubitril
Author(s) -
Kaur Amanpreet,
Gehlawat Anju,
Prakash Ranjana,
Pandey Satyendra Kumar
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202102506
Subject(s) - enantioselective synthesis , sacubitril , total synthesis , sacubitril, valsartan , valsartan , alkylation , chemistry , combinatorial chemistry , stereochemistry , medicine , organic chemistry , catalysis , blood pressure
An efficient enantioselective approach of Sacubitril 1 (a NEP inhibitor) which is used as a combination drug with Valsartan to treat heart failure, is described. The synthesis features the Evan's asymmetric alkylation, Sharpless asymmetric diydroxylation (AD) and Heck coupling reactions as key steps.
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