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Copper Metallogel as Potential Drug Carrier for Anti‐Inflammatory Drugs
Author(s) -
Choudhary Priyanka,
Gaur Ruchi,
Rambabu Darsi,
Dhir Abhimanew,
Gupta Ankush
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202102490
Subject(s) - drug , ibuprofen , tricarboxylic acid , chemistry , copper , benzene , pharmacology , nuclear chemistry , organic chemistry , citric acid cycle , medicine , enzyme
Copper based Metal‐Organic Gels (MOGs) were evaluated for their efficiency as drug carrier for four anti‐inflammatory drugs viz . 5‐Fluorouracil (5FU), Phenidone (PN), Ibuprofen (IBP) and Cisplatin (CP). Copper(II)‐benzene tricarboxylic acid (CuBTC) was used as a precursor for the loading and releasing of these drugs. The distinctive porous nature of the gel provided the high loading efficiency for these anti‐inflammatory drugs. Among all the drugs evaluated, CuBTC@5FU exhibited maximum drug loading (88.1 %) and releasing (95 %) efficiency at physiological pH 5.2, which was attributed to the strong hydrogen bonding interactions between CuBTC and fluoride of 5FU.