Premium
Metal‐Free Intramolecular Hydroalkoxylation of Alkyne: Recent Advances
Author(s) -
Nanda Santosh K.
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202102426
Subject(s) - alkyne , cascade , intramolecular force , combinatorial chemistry , chemistry , enantioselective synthesis , metal , catalysis , organic chemistry , chromatography
Hydroalkoxylation of alkyne offers a unique platform to rapidly access structurally complex and densely functionalized oxygen‐bearing heterocycles. Further, to enhance the synthetic utility, various cascade reactions including hydroalkoxylation have been reported in both stereo‐ as well as enantioselective manner under metal and metal‐free conditions. A collection of the most representative and recent methods employing metal‐free hydroalkoxylation events are presented in this review article.