Premium
Design, Synthesis, Evaluation and Molecular Docking Studies of 1,6‐Bis‐triazole‐Linked α ‐Galactoside Derivatives as Potential Anticancer Agents
Author(s) -
Chaidam Suksamran,
Saehlim Natthiya,
Suksen Kanoknetr,
Chairoungdua Arthit,
Saeeng Rungnapha
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202102288
Subject(s) - cytotoxicity , docking (animal) , chemistry , in vitro , stereochemistry , click chemistry , triazole , cytotoxic t cell , galactoside , molecular model , biochemistry , 1,2,3 triazole , combinatorial chemistry , enzyme , organic chemistry , medicine , nursing
A series of novel 1,6‐bis‐triazole‐linked α ‐galactoside derivatives ( 5 a – 5 bb ) were designed and synthesized in high yields through O ‐Glycosylation and click chemistry. All analogues were evaluated for their in vitro cytotoxic activity against nine cancer cell lines. Cytotoxicity results demonstrate that compounds 5 o and 5 bb showed significant cytotoxic activities against leukemia (P‐388, IC 50 =4.45 μM) and cholangiocarcinoma (K‐100, IC 50 =4.87 μM) cancer cells. Molecular docking studies of active compounds displayed good binding energies towards both CDK‐2 and EGFR proteins, correlated with their in vitro results.