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Cu/Pd‐Catalyzed One‐Pot Synthesis of 2‐(1,2,3‐Triazolyl)methyl‐3‐alkynylImidazo[1,2‐ a ]pyridines Involving Sequential SN Reaction/[3+2] Cycloaddition/Sonogashira Coupling Reactions
Author(s) -
Qami Abdelkarim El,
Jismy Badr,
El Hakmaoui Ahmed,
Akssira Mohamed,
Abarbri Mohamed
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202102228
Subject(s) - sonogashira coupling , cycloaddition , chemistry , catalysis , one pot synthesis , regioselectivity , medicinal chemistry , combinatorial chemistry , 1,2,3 triazole , coupling reaction , organic chemistry , palladium
An efficient one‐pot regioselective synthesis of 2‐(1,2,3‐triazolyl)methyl‐3‐alkynyl imidazo[1,2‐ a ]pyridines is reported under simple and mild reaction conditions. The new imidazo[1,2‐ a ]pyridines embedded with 4‐substituted‐[1,2,3]‐triazole were obtained in good to excellent yields from 2‐(chloromethyl)‐3‐iodo imidazo[1,2‐ a ]pyridines via a one‐pot sequence involving an SN reaction with azide, followed by copper‐catalyzed [3+2]cycloaddition and a Sonogashira coupling reaction.