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Synthesis of Carboxylic Acids, Esters, and Amides from 1,1‐Dibromoalkenes via Oxidation of Alkynyl Boronate Intermediates
Author(s) -
Tao Lei,
Yang Wen,
Zhao Wanxiang
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202102150
Subject(s) - chemistry , combinatorial chemistry , functional group , oxidation process , substrate (aquarium) , primary (astronomy) , organic chemistry , oceanography , physics , pulp and paper industry , astronomy , engineering , geology , polymer
An efficient and practical method for the synthesis of carboxylic acids, esters, and amides from 1,1‐dibromoalkenes has been developed. The reactions proceed through a key process, the C(sp)−B bond oxidation of alkynyl boronate intermediates with Oxone. This protocol features broad substrate scope, good efficiency, and good functional group compatibility. Moreover, the synthetic practicability was demonstrated by easy gram‐scale preparation and the synthesis of drug molecules.