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Substituted, Bicyclic 3‐Benzoyl Flavanones Synthesis by Highly Efficient N‐Heterocyclic Carbene (NHC) Catalysis
Author(s) -
Singh Ashmita,
Narula Anudeep Kumar
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101877
Subject(s) - carbene , catalysis , bicyclic molecule , flavanone , chemistry , salicylaldehyde , organic chemistry , ethanol , medicinal chemistry , combinatorial chemistry , stereochemistry , flavonoid , antioxidant , schiff base
A new methodology for the synthesis of substituted, bicyclic 3‐benzoyl flavanone derivatives by [4+2] annulations of salicylaldehyde with chalcones in the presence of N‐heterocyclic carbene (NHC) as a catalyst, I 2 as co‐catalyst and tert ‐butyl hydroperoxide (TBHP) as an oxidant in ethanol was developed. The effectiveness of the developed methodology was proved with an array of electron‐deficient to electron‐rich substrates.