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Preparation and Properties of Hollow Magnetic Liquid Crystal Molecularly Imprinted Polymers as Silybin Sustained‐release Carriers
Author(s) -
Tan Ni,
Chen Can,
Ji Kang,
Liao Sen,
Liu Yaqing,
Hu Lin,
He Leqing,
Ding Zui
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101786
Subject(s) - adsorption , molecularly imprinted polymer , polymer , selectivity , atom transfer radical polymerization , chemistry , linker , polymerization , chromatography , chemical engineering , organic chemistry , catalysis , computer science , engineering , operating system
In this work, a new drug carrier, the hollow magnetic silybin liquid crystal molecular imprinted polymer (HMS@LC‐MIP) was prepared through the reverse atom radical transfer polymerization(RATRP) method. In order to decrease the degree of cross‐linker, the liquid crystal ingredient methylphenyl dicyclohexyl ethylene, a kind of physical cross‐linker, being able to replace the chemical cross‐linker partly, was introduced into the synthetic system. The characterizations of HMS@LC‐MIPs were investigated by FT‐IR, VSM, TEM and so on. A series of adsorption experiments showed the maximum adsorption capacity and the adsorption equilibrium time of HMS@LC‐MIP were 18.53 mg g −1 and 180 min, respectively, and the relative selectivity factor β =2.06 implied HMS@LC‐MIP had the high selectivity to the template. The in‐vitro release experiments exhibited HMS@LC‐MIP possessed the good responsiveness to pH values and the desirable slow release performance with 48 h of sustaining time. In short, the HMS@LC‐MIP should be of a potential as drug sustained‐release agent in the future.