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NBS‐Promoted C−H Amination of Enaminones for the Synthesis of N‐Heterocycle Substituted Enaminones **
Author(s) -
Duan Xiyan,
Li Huimin,
Li Weinan,
Wang Junqi,
Liu Ning
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101726
Subject(s) - amination , halogenation , intermolecular force , nucleophile , chemistry , catalysis , combinatorial chemistry , transition metal , transformation (genetics) , medicinal chemistry , organic chemistry , molecule , biochemistry , gene
A NBS‐promoted C−H amination of enaminones has been developed with a variety of N‐heterocycles. This methodology is highly practical as it employs inexpensive and simple NBS promotor under aerobic conditions without the additions of any transition metal catalyst. The transformation proceeds by the initial bromination of enaminones and the subsequent intermolecular substitution with N‐nucleophile to form C−N bond.