Brønsted Acid Promoted  N ‐Dealkylation of  N ‐Alkyl(sulfon)amides | Zendy

Gu Linghui | Zendy; Wang Yang | Zendy; Cheng Zemin | Zendy; Sun Yanan | Zendy; Gong Xin | Zendy; Li Zheyu | Zendy; Ma Wenbo | Zendy

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Brønsted Acid Promoted N ‐Dealkylation of N ‐Alkyl(sulfon)amides

Author(s) -

Gu Linghui,

Wang Yang,

Cheng Zemin,

Sun Yanan,

Gong Xin,

Li Zheyu,

Ma Wenbo

Publication year - 2021

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.202101676

Subject(s) - alkylation , alkyl , amide , catalysis , brønsted–lowry acid–base theory , chemistry , selectivity , organic chemistry , substrate (aquarium) , scope (computer science) , primary (astronomy) , computer science , biology , ecology , physics , astronomy , programming language

A simple and efficient Brønsted‐acid‐promoted N ‐dealkylation of N ‐alkylamides and N ‐alkylsulfonamides has been developed. This strategy features an ample substrate scope with excellent chemical selectivity, affording primary (sulfon)amide derivatives in moderate to good yields without the need for transition‐metal catalysts.

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