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Brønsted Acid Promoted N ‐Dealkylation of N ‐Alkyl(sulfon)amides
Author(s) -
Gu Linghui,
Wang Yang,
Cheng Zemin,
Sun Yanan,
Gong Xin,
Li Zheyu,
Ma Wenbo
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101676
Subject(s) - alkylation , alkyl , amide , catalysis , brønsted–lowry acid–base theory , chemistry , selectivity , organic chemistry , substrate (aquarium) , scope (computer science) , primary (astronomy) , computer science , biology , ecology , physics , astronomy , programming language
A simple and efficient Brønsted‐acid‐promoted N ‐dealkylation of N ‐alkylamides and N ‐alkylsulfonamides has been developed. This strategy features an ample substrate scope with excellent chemical selectivity, affording primary (sulfon)amide derivatives in moderate to good yields without the need for transition‐metal catalysts.