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Synthesis and Functionalization of Imidazo[1,2‐ b ]Pyridazine by Means of Metal‐Catalyzed Cross‐Coupling Reactions
Author(s) -
El Akkaoui Ahmed,
Koubachi Jamal,
Guillaumet Gérald,
El Kazzouli Saïd
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101636
Subject(s) - pyridazine , stille reaction , sonogashira coupling , negishi coupling , surface modification , chemistry , combinatorial chemistry , catalysis , alkylation , palladium , organic chemistry , medicinal chemistry
This review surveys the recent developments in organometallic‐chemistry‐based methods for the preparation of imidazo[1,2‐ b ]pyridazines by cyclization as well as their functionalization by means of cross‐coupling reactions such as Sonogashira, Heck, Negishi, Suzuki‐Miyaura, Kumada and Stille. In addition, the advances made on the C−H activation of imidazo[1,2‐ b ]pyridazines using C‐arylation, C‐benzylation and C‐alkylation are also reviewed. Furthermore, the recent reports on the N ‐arylation of this heterocyclic system are discussed and highlighted. The sequential couplings as well as the one‐pot functionalization of two different positions on the imidazo[1,2‐ b ]pyridazine systems are also reviewed. Procedures in which metal‐based catalysis is not involved in the functionalization of imidazo[1,2‐ b ]pyridazines are not included in this review.