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A photosensitized metal free approach to α‐ketoamides:sequential oxidative amidationdiketonization of terminal alkynes
Author(s) -
Manhas Farah Manzer,
Raheem Shabnam,
Kumar Jaswant,
Thakur Pankaj,
Rizvi Masood Ahmad
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101511
Subject(s) - thiophenol , rose bengal , visible spectrum , photochemistry , chemistry , oxidative coupling of methane , oxidative phosphorylation , functional group , combinatorial chemistry , photosensitizer , organic chemistry , catalysis , materials science , biochemistry , polymer , optoelectronics
Abstract A novel transition metal‐free photosensitized protocol has been developed for the synthesis of α‐ketoamides via oxidative coupling of alkynes and amines in the presence of thiophenol under visible light irradiation and rose bengal dye. A series of alkynes with both electron‐donating and electron‐withdrawing groups were successfully employed for the synthesis of their corresponding α‐ketoamides. This reaction presents a benign visible light based milder synthetic methodology with broad functional‐group tolerance.