Premium
Amidation and Intramolecular Aza‐Michael Reaction: One‐Pot Synthetic Strategy of Isoindolinones
Author(s) -
Asraf Ali Sk,
Bera Anirban,
Rahaman Molla Mijanur,
Samanta Shubhankar
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101259
Subject(s) - michael reaction , intramolecular force , chemistry , amine gas treating , catalysis , aryl , alkoxy group , acrylate , organic chemistry , combinatorial chemistry , alkyl , medicinal chemistry , copolymer , polymer
Herein, we report one‐pot Cu(I) catalyzed open flask synthetic strategy of 3‐substituted N ‐pyridinyl isoindolinones from alkyl ( E )‐3‐(2‐formylphenyl)acrylate by oxidative amidation and intramolecular aza‐Michael reaction using cheap air stable Cu(I) single catalyst. We have also established a synthetic route of N ‐aryl substituted isoindolinones with acid‐amine coupling reaction of ( E )‐2‐(3‐alkoxy‐3‐oxoprop‐1‐en‐1‐yl)benzoic acid followed by aza‐Michael reactions. Unexpected synthetic route of N ‐(1H‐inden‐1‐yl)pyridin‐2‐amine derivatives have been documented from the same precursors using Cu(I) catalyst.