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Synthesis and Evaluation of Anticancer Activity of Pyrazolone Appended Triarylmethanes (TRAMs)
Author(s) -
Kshatriya Rajpratap,
Shelke Premchand,
Mali Suraj,
Yashwantrao Gauravi,
Pratap Amit,
Saha Satyajit
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202101083
Subject(s) - pyrazolone , hela , chemistry , combinatorial chemistry , docking (animal) , in silico , catalysis , molecule , cancer cell lines , in vitro , organic chemistry , cancer cell , biochemistry , cancer , biology , medicine , nursing , gene , genetics
The present work describes the design, synthesis, and evaluation of the anticancer properties of pyrazolone ring appended triarylmethanes by the condensation of diarylmethanols with pyrazolone in presence of a catalytic amount of p‐TSA catalyst. The use of an inexpensive catalyst and accessing the desired product in good yields within a short span are the merits associated with this protocol. Furthermore, the in‐silico, as well as in‐vitro analysis and molecular docking of the designed molecules, were performed followed by their anticancer activity evaluation against cancer cell lines like MCF7, MDA‐MB‐231, HeLa, and DU‐145. Few of the synthesized molecules demonstrated significant anticancer activity and could provide a new direction in the development of anti‐cancer molecules.