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Metal‐Free Synthesis of 2‐Aryl Quinazolines via Tandem C−H/N−H Bond Functionalization
Author(s) -
Yuan Feixiang,
Xie Shihua,
Zhuo Liang,
Wang Lei,
Zhu Hongjun
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100990
Subject(s) - surface modification , tandem , chemistry , aryl , combinatorial chemistry , substrate (aquarium) , reagent , organic synthesis , functional group , organic chemistry , catalysis , materials science , polymer , alkyl , oceanography , composite material , geology
C−N bond formation is crucial for the preparation of synthetic organic nitrogen‐containing heterocyclic compounds. This work provides a facile and highly efficient strategy (ca. ∼92 %) for the synthesis of quinazoline compounds, which involves tandem C−H/N−H bond functionalization using metal‐free conditions without the need for an external oxidant. Meanwhile, the reaction system exhibits good functional group tolerance and a wide substrate scope. Furthermore, our corresponding isotope tracking experiments have shown that dimethyl sulfoxide acts as a carbon source. Finally, this work affords a new strategy toward the further design and synthesis of heteroaromatic rings.