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Starch‐Based Membranes for Controlled Release of 5‐Fluorouracil In Vitro
Author(s) -
Berkkan Aysel,
Kondolot Solak Ebru,
Asman Gulsen
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100917
Subject(s) - membrane , starch , permeation , vinyl alcohol , chemistry , polymer , synthetic membrane , chemical engineering , polymer chemistry , transdermal , nuclear chemistry , materials science , chromatography , organic chemistry , biochemistry , medicine , engineering , pharmacology
Starch is a natural polymer that is among the sustainable materials and has the characteristics of being a green material in harmony with nature. In this study, a potential transdermal release system was evaluated by investigating 5‐fluorouracil (5‐FU) transfer through starch/poly(vinyl alcohol) (PVA) membranes in vitro. The effects of membrane thickness, starch/PVA blending ratio, pH, and temperature on the release of 5‐FU from the membranes were studied. At the end of the study, it was deduced that decrease in pH reduces the released amount of 5‐FU from starch/PVA membranes and 5‐FU transfer from membranes could be controlled within a fairly constant range. The diffusion coefficient was determined as 4.84 × 10 −3 , 4.49 × 10 −3 and 2.54 × 10 −3 cm 2 s −1 for the pH of 7.4, 5.5, and 3.5, respectively. The activation energy for the permeation 5‐FU from starch/PVA membrane (60/40, v/v) was found to be 9.72 kJ mol −1 .