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Synthesis of Multisubstituted Indanedione Based Spiropyrans via Oxa‐Michael/Michael Cascade Reaction
Author(s) -
Reddy Yeruva Pavankumar,
Gudise Veera Babu,
Settipalli Poorna Chandrasekhar,
Anwar Shaik
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100915
Subject(s) - stereocenter , michael reaction , cascade , nitro , ring (chemistry) , spiropyran , chemistry , cascade reaction , allylic alcohol , allylic rearrangement , combinatorial chemistry , stereochemistry , organic chemistry , molecule , chromatography , catalysis , alkyl , enantioselective synthesis
A sequential formal [4+2] cyclization involving cascade protocol has been developed for the construction of multisubstituted six‐membered spirocyclic scaffolds by using 2‐arylidene‐1, 3‐indanedione and nitro allylic alcohol. This method generates four stereocenters in spiropyran ring with high diastereoselctivity (99 : 1) under mild reaction conditions.