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Tuning the Reactivity and Bonding Properties of the Pt(II) Complexes by the Substitution(s) on the Trans‐Coordinated Non‐Aromatic Amine Ligand
Author(s) -
Dvořáčková Olga,
Chval Zdeněk
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100887
Subject(s) - chemistry , ligand (biochemistry) , substituent , reactivity (psychology) , dimethylamine , medicinal chemistry , trans effect , pyridine , stereochemistry , isomerization , polar effect , crystallography , crystal structure , organic chemistry , catalysis , biochemistry , alternative medicine , receptor , medicine , pathology
Kinetics of the hydration reaction and the bonding properties of the trans ‐[Pt(NH 3 ) 2 (NH 2 X)Cl] + complexes (X=H, CH 3 , F, Cl, Br, NH 2 , NO 2 , OH, dimethylamine (DMA), cyclopropyl (CyP), cyclohexyl (CyH)) were studied theoretically by DFT methodology in the gas phase and the water solution. The electron‐donating and electron‐withdrawing X substituents lower and increase, respectively, the activation free energy (ΔG ≠ ) and Pt‐trans ligand binding energies (BEs) to a similar extent as meta and para substituents of the pyridine ligand studied previously (ACS Omega, 2020, 5, 11768). For the saturated hydrocarbon X substituents (X=H, CH 3 , CyP, CyH), the ΔG ≠ values and Pt‐trans ligand BEs decrease with the logarithm of the X substituent size being best quantified by the number of electrons. The additivity of the substituent effects was studied on the NF 3 ligand and worked well for ligand charges and Pt−trans ligand BEs. The influence of chelation was evaluated by the comparison of the CyH system and the complexes with the cyclohexanediamine (DACH) ligand. Finally, the effect of isomerization was studied on the complexes with the 1,2 ‐ bis(aminomethyl)cyclobutane (BAMCB) ligand. Thus, this study also evaluates the influence of the non‐leaving ligands present in cisplatin, oxaliplatin, lobaplatin, JM118, and JM11 drugs on the reactivity of the Pt(II) complexes in the same ligand environment.