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Sustainable Synthesis of Amides from Ethyl 3‐(4‐Hydroxyphenyl) Propionate
Author(s) -
Lima Rafaely N.,
L. L. Vaz Artur,
Clososki Giuliano C.,
Porto André L. M.
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100883
Subject(s) - candida antarctica , amide , environmentally friendly , catalysis , chemistry , propionate , organic chemistry , organic synthesis , continuous flow , lipase , flow chemistry , combinatorial chemistry , enzyme , biochemical engineering , biology , ecology , engineering
Biocatalytic methods have shown to be a versatile choice for obtaining a large number of organic compounds under a non‐natural reaction condition. Another efficient approach is the continuous‐flow system, which when combined with enzyme catalysis can make the process even more environmentally friendly. Based on this, amides from ethyl 3‐(4‐hydroxyphenyl) propanoate were obtained, catalyzed by Lipase B of Candida Antarctica (CAL−B) (41 %–75 %, 6–24 h) or in a free solvent/catalyst system (69–99 %, 72 h). The efficiency of amide synthesis was improved using a continuous‐flow system, reducing the reaction time to 10 min of residence in presence of CAL−B. These results represent a contribution to the sustainable synthesis of compounds with cosmetic potential and pharmacological properties.