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Sulfur Catalyzed Metal‐ and Solvent‐Free ABB'C Four‐Component Synthesis of N ‐Arylidene‐2‐aryl‐imidazo[1‐2‐ a ]azin‐3‐amines via Strecker Reaction
Author(s) -
Pavithra Thangavel,
Devi E. Sankari,
Nagarajan Subbiah,
Sridharan Vellaisamy,
Maheswari C. Uma
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100682
Subject(s) - strecker amino acid synthesis , trimethylsilyl cyanide , chemistry , catalysis , aryl , sulfur , organic chemistry , solvent , aminopyridines , cyanide , trimethylsilyl , medicinal chemistry , alkyl , enantioselective synthesis
An efficient ABB'C four‐component Strecker reaction between 2‐aminopyridines, aromatic aldehydes and trimethylsilyl cyanide (TMSCN) was developed under metal‐ and solvent‐free conditions to access N ‐arylidene‐2‐aryl‐imidazo[1,2‐ a ]azin‐3‐amines in high yields. This one‐pot reaction was carried out in the presence of elemental sulfur as catalyst using readily available starting material at room temperature. The reaction was tolerant to several substituted 2‐aminopyridines and aryl aldehydes and have good green chemistry metrics as compared to the reported methods.