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Metal‐Free Synthesis of Alkyl Phenyl Selenides by Reaction of Activated Alcohols with the O‐(tert‐ Butyl) Se ‐Phenyl Selenocarbonate/HI System
Author(s) -
Temperini Andrea,
Ballarotto Marco,
Siciliano Carlo
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100602
Subject(s) - alkyl , chemistry , metal , medicinal chemistry , organic chemistry , group (periodic table) , alcohol
The reaction of activated alcohols with the O ‐( tert ‐butyl) Se ‐phenyl selenocarbonate/hydroiodic acid system to give the corresponding alkyl phenyl selenides is described. The direct conversion of the hydroxyl group into a phenylselenenyl group is also extended to allyl‐ and tertiary alkyl alcohols. This work provides a safe, metal‐free, and operationally simple process for the preparation of alkyl phenyl selenides from benzylic alcohols.