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Synthesis of 9‐O‐Arylated Berberine with a Polystyrene Resin Supported Copper(II) Catalyst
Author(s) -
Meng Qi,
Zhang Lian,
Zhu Xinhui,
Teng Qiaoqiao
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100525
Subject(s) - catalysis , polystyrene , aniline , copper , polymer chemistry , berberine , chemistry , pyridine , coupling reaction , porosity , nuclear chemistry , organic chemistry , polymer
A series of polyfluorobenzene, pyridine and aniline substituted berberine derivatives ( 3 b – 3 h ) were prepared via resin‐supported Cu(II) catalyzed cross‐coupling reactions of tetrahydroberberrubine with iodoarenes and subsequent I 2 oxidation. The best catalyst, a polyethyleneimine functionalized polystyrene supported Cu 2+ (PSAPA⋅Cu(II)), could be reused for at least 5 runs without significant loss of catalytic activity. Comparative studies on the morphology and porous structures of the materials suggested a catalyst with a moderate specific surface area and larger pore diameters was more active in catalyzing the cross‐coupling reactions.