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In‐Silico Tuning of Curcumin Loading on PEG Grafted Chitosan: An Atomistic Simulation
Author(s) -
Sohrabi Somayeh,
Khedri Mohammad,
Maleki Reza,
Moraveji Mostafa Keshavarz,
Ghasemy Ebrahim
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100354
Subject(s) - curcumin , polyethylene glycol , biocompatibility , chitosan , peg ratio , drug delivery , materials science , polymer , chemical engineering , peg 400 , chemistry , nanotechnology , organic chemistry , composite material , biochemistry , finance , engineering , economics
In this work, trimethyl chitosan grafted polyethylene glycol (PEG) was employed to optimize the curcumin loading, which is a natural bioactive substance with a good anti‐cancerous effect. It is vital to develop a novel carrier to increase the therapeutic effect of curcumin and decrease its hydrophobicity. Biocompatibility and hydrophilicity of the PEG cause it to be one of the most attractive drug carriers. Chitosan is also of great importance, considering its biocompatibility, and is used along with the drug‐carrying polymers. In this work, interaction energies, stability, hydrophilicity, and other molecular properties of the curcumin‐loaded PEG‐chitosan nanohybrid have been investigated. Atomistic analysis showd that the optimum concentration of chitosan is 60 % and optimum concentration of PEG is 40 %. In addition to concentration, the effect of PEG chain length, which is one of the important parameters of this circimin delivery system, has been also studied. The current work gives an atomistic insight into curcumin delivery and suggests a new curcumin delivery system.