Premium
Transition Metal Free α −C−H Functionalization of Six Membered Heteroaromatic‐ N ‐Oxides
Author(s) -
Kaur Ramandeep,
Mandal Sudip,
Banerjee Debolina,
Kumar Yadav Ashok
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100319
Subject(s) - surface modification , reagent , transition metal , nucleophile , chemistry , halogen , combinatorial chemistry , metal , polymer chemistry , organic chemistry , catalysis , alkyl
Abstract A comprehensive account of transition metal free α −C−H functionalization of six membered heteroaromatic‐ N ‐oxides has been discussed in this review article. This review includes brief account of explanatory text with schemes, effect of substituents on the reaction and limitation of reaction for transition metal free α −C−H functionalization of six membered heteroaromatic‐ N ‐oxides. Schemes depict the reaction conditions along with a quick look into their mechanism. Each of the reported example has been considered for reacting substrates such as readily available different six membered heteroaromatic‐ N ‐oxides, activating reagents, reaction conditions and different types of nucleophiles (N, Halogens, P, S, C and O), reaction conditions and reagents used for transition metal free α −C−H functionalization of six membered heteroaromatic‐ N ‐oxides. This review will be supportive to the chemists in understanding the challenges associated with the reported methods as well as the future potentials, both in the choice of substrates and reagents.