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Photoinduced Activation of Unactivated C( sp 3 )‐H Bonds and Acylation Reactions
Author(s) -
Ren ChenChao,
Wang TianQi,
Zhang Yu,
Peng Dao,
Liu XiaoQing,
Wu QingAn,
Liu XueFen,
Luo ShuPing
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100225
Subject(s) - benzophenone , acylation , chemistry , yield (engineering) , catalysis , photochemistry , hydrogen atom , medicinal chemistry , ketone , organic chemistry , group (periodic table) , materials science , metallurgy
An efficient and benign method of C ( sp 3 )‐H acylation based on the direct conversion of stable amides has been established. This photoredox cross‐coupling of amides and methylbenzenes for aromatic ketones is enabled by the cheap benzophenone photocatalyst and nickel catalyst, with high yield (up to 90 %). The benzophenone catalyst having electron‐withdrawing group promotes the efficiency of hydrogen atom transfer, which is beneficial to improve the yield.