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Cyclodesulfurization: An Enabling Protocol for Synthesis of Various Heterocycles
Author(s) -
Kadagathur Manasa,
Shaikh Arbaz Sujat,
Jadhav Govinda Shivaji,
Sigalapalli Dilep Kumar,
Shankaraiah Nagula,
Tangellamudi Neelima D.
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100201
Subject(s) - combinatorial chemistry , ring (chemistry) , sulfur , chemistry , organic synthesis , nanotechnology , computer science , biochemical engineering , organic chemistry , materials science , engineering , catalysis
Heterocycles closely intertwine chemistry with biology reflecting the presence of nitrogen‐based heterocyclic ring structure in nearly 75 % of small‐molecule drugs. The number of reported strategies for the synthesis of several “privileged scaffolds” has expanded, amongst which, cyclodesulfurization of thioureas offers a quick access to highly substituted heterocycles, thereby playing a role of an excellent tool in organic syntheses of natural products and pharmaceutically active compounds. This comprehensive review emphasizes the applications of cyclodesulfurization as an integral synthetic step in the synthesis of nitrogen, oxygen and sulfur‐containing heterocycles. Furthermore, a survey of cyclodesulfurizing agents reported since 2000 is comprehensively reviewed and summarized.