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Microwave‐Assisted Iron(III)Chloride Catalyzed One‐Pot Michael Addition‐Cyclization for the Synthesis of 6 H ‐Chromeno[4’,3’:4,5] imidazo[1,2‐a]pyridine
Author(s) -
Mishra Mitali,
Mishra Nilima P.,
Raiguru Bishnu P.,
Das Tapaswini,
Mohapatra Seetaram,
Nayak Sabita,
Mishra Deepak R.,
Panda Jasmine,
Sahoo Dipak K.
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100165
Subject(s) - pyridine , chemistry , yield (engineering) , anhydrous , microwave irradiation , catalysis , combinatorial chemistry , aryl , medicinal chemistry , organic chemistry , materials science , alkyl , metallurgy
An efficient one‐pot Michael addition‐cyclization reaction has been developed for the synthesis of 6 H ‐chromeno[4’,3’ : 4,5]imidazo[1,2‐a]pyridine under microwave irradiation method. The current protocol paves the way for the synthesis of twenty number of structurally diversified imidazo[1,2‐ a ]pyridines in high yield by the reaction of substituted 2‐aryl‐3‐nitro‐2 H ‐chromenes with 2‐aminopyridines using anhydrous iron(III)chloride. This current protocol is the first report of the preparation of this medicinally significant highly substituted 6 H ‐chromeno[4’,3’ : 4,5]imidazo[1,2‐a]pyridine derivatives under microwave irradiation in good to high yields. The tolerance of a wide range of functional groups, operational simplicity and short reaction times are the significant advantages of this protocol.