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Highly Efficient Synthesis of N ‐Alkyl‐α‐amino Acid Methyl Esters by Microwave Irradiation
Author(s) -
Ghaffari Saeedeh,
Kazemi Foad
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100114
Subject(s) - alkyl , alkylation , chemistry , amino acid , microwave irradiation , organic chemistry , irradiation , medicinal chemistry , biochemistry , catalysis , physics , nuclear physics
In this report at first we prepared N ‐nosyl‐ α ‐amino acid methyl esters from α ‐amino acids in a simple method, with short reaction times and good yields. Then, N ‐nosyl‐ α ‐amino acid methyl esters were N ‐alkylated using alkyl tosylates under microwave irradiation to produce N ‐alkyl‐ N ‐nosyl‐α‐amino acid methyl esters in convenient times and with good yields. At the end, efficient and convenient deprotection of o ‐nitrobenzenesulfonyl group with use of HSCH 2 CH 2 OH/K 2 CO 3 was done to produced N ‐alkyl‐ α ‐amino acid methyl esters.