Premium
Visible Light Mediated, Photocatalyst‐Free Condensation of Barbituric Acid with Carbonyl Compounds
Author(s) -
Kumari Savita,
Kumar Maury Suresh,
Kumar Singh Himanshu,
Kamal Arsala,
Kumar Dhirendra,
Singh Sundaram,
Srivastava Vandana
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100051
Subject(s) - barbituric acid , isatin , chemistry , aldehyde , oxindole , molecule , yield (engineering) , condensation , photochemistry , catalysis , organic chemistry , materials science , physics , metallurgy , thermodynamics
An economical and efficient method has been developed for the production of dibarbiturates of oxindole and arylidene barbituric acid derivatives via condensation of of isatin/aryl aldehyde with barbituric acid, through irradiation of visible light. Under the similar conditions 2 molecules of barbituric acid react with 1 molecule of isatin while only 1 molecule of barbituric acid reacts with 1 molecule of aldehyde. This transformation involves catalyst free pathway for the formation of desired products under mild reaction conditions. Metal free reaction conditions, high yield of products along with the absence of side‐products are additional green features of this protocol.