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(NH 4 ) 2 [Ni(H 2 O) 6 ] 2 V 10 O 28 ⋅ 4H 2 O; Structural Analysis and Bactericidal Activity against Pathogenic Gram Negative Bacteria
Author(s) -
Mahmoud Ghada AbdElmonsef,
Ibrahim Ahmed B. M.,
Mayer Peter
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100006
Subject(s) - escherichia coli , triclinic crystal system , nuclear chemistry , serratia marcescens , chloramphenicol , chemistry , crystal structure , stereochemistry , crystallography , antibiotics , biochemistry , gene
A bis(hexaaquanickel(II)) complex‐decavanadate cluster compound, (NH 4 ) 2 [Ni(H 2 O) 6 ] 2 V 10 O 28 ⋅ 4H 2 O, was synthesized. This compound has been structurally characterized by infrared spectroscopy and single crystal XRD analysis that indicated its triclinic P −1 space group. Additionally, the thermal decomposition mechanism of the compound to a composite of V 2 O 5 and Ni(VO 3 ) 2 was elucidated. The common antibacterial agents are organics that experience instability and cause pollution to the environment, therefore we wish to consider the synthesis of inorganic bactericides. (NH 4 ) 2 [Ni(H 2 O) 6 ] 2 V 10 O 28 ⋅ 4H 2 O, in comparison to chloramphenicol, led to better inhibition of the growth of five Gram negative human pathogenic bacterial strains ( Escherichia coli, Klebsiella pneumonia, Serratia marcescens, Serratia plymuthica and Pseudomonas aeruginosa) . Remarkably, the highest inhibition was displayed against Escherichia coli that was inhibited completely at (NH 4 ) 2 [Ni(H 2 O) 6 ] 2 V 10 O 28 ⋅ 4H 2 O (50 μg/ml), while the Escherichia coli growth was of 12.93×10 7 ±0.25 CFU/ml at (NH 4 ) 2 [Ni(H 2 O) 6 ] 2 V 10 O 28 ⋅ 4H 2 O (5 μg/ml). This is in contrast to chloramphenicol (5 μg/ml) that allowed for Escherichia coli growth of 13.97×10 7 ±0.24 CFU/ml (control=17.33×10 7 ±0.48 CFU/ml).