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Cu(II)‐Catalysed Azide‐Alkyne Cycloaddition Reaction towards Synthesis of β‐Carboline C1‐Tethered 1,2,3‐Triazole Derivatives
Author(s) -
Kumar Sunit,
Malakar Chandi C.,
Singh Virender
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202100002
Subject(s) - cycloaddition , click chemistry , indole test , azide , alkyne , combinatorial chemistry , chemistry , triazole , 1,2,3 triazole , molecule , stereochemistry , catalysis , organic chemistry
Indole and β‐carboline alkaloids exhibit diverse range of significant pharmacological properties as reflected by their contribution in drug‐discovery. We have described the synthesis of hybrid molecules containing β‐carboline C1‐linked 1,2,3‐triazoles in moderate to good yields. The developed transformation was realized by using Cu(II)‐catalysed click‐reaction of diverse alkynes with in‐situ derived rarely explored β‐carboline tethered aliphatic azides. These molecular hybrids also exhibited excellent fluorescence properties.