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In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2‐b]qinoline Amines Supported with Molecular Docking and MCDM **
Author(s) -
Aydın Ali,
Ökten Salih,
Erkan Sultan,
Bulut Merve,
Özcan Evrencan,
Tutar Ahmet,
Eren Tamer
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202004753
Subject(s) - hela , quinoline , chemistry , docking (animal) , cytotoxicity , combinatorial chemistry , stereochemistry , in vitro , amine gas treating , antibacterial activity , molecular model , biochemistry , organic chemistry , bacteria , biology , medicine , nursing , genetics
The present study describes mono substituted indeno[1,2‐b]quinolines ( 3 a – c and 5 ) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC 50 values 1.1–29.6 μg/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2‐b]quinoline amines ( 3 a – c and 5 ) exhibit significant antimicrobial activity with MIC values between 15.62 μg/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×10 3 –1.1×10 5 M −1 . The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi‐criteria decision‐making methodology (MCDM) indicated that the mono substituted indeno[1,2‐b]quinoline amine derivatives, especially 3 a and 5 , exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level.