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A Green and Efficient Protocol for the Synthesis of Phenylhydrazone Derivatives Catalyzed by Nanostructured Diphosphate Na 2 CaP 2 O 7 and Screening of Their Antibacterial Activity
Author(s) -
Achagar Redouane,
Elmakssoudi Abdelhakim,
Dakir Mohamed,
Elamrani Abdelaziz,
Zouheir Yassine,
Zahouily Mohamed,
Jamaleddine Jamal
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202004671
Subject(s) - antibacterial activity , catalysis , chemistry , combinatorial chemistry , gram , solvent , nuclear chemistry , organic chemistry , bacteria , biology , genetics
A new efficient strategy using diphosphate Na 2 CaP 2 O 7 (DPH) for the synthesis of phenylhydrazone derivatives in solvent‐free media is described. The synthesis of eight variously substituted phenylhydrazone derivatives ( 3 a to 3 h ) can be carried out with a small amount of the catalyst, which can be easily recovered and reused several times without significant loss in catalytic activity. This protocol developed in our study is considered simple, clean, and characterized by short reaction time and high conversion. The antibacterial activity was evaluated for the synthesized compounds against Gram‐positive and Gram‐negative strains. A structure‐activity relationship (SAR) study and the connection between antibacterial activity of the compounds was discussed and showed that electron donating groups increase the antibacterial activity.