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Ultrasound‐Assisted Expeditious Catalyst‐Free Green Approach towards Diastereoselective Synthesis of Spiro[indoline‐3,2′‐pyrido[2,1‐ b ][1,3]oxazine]‐3′,4′‐dicarboxylate Scaffolds
Author(s) -
Mal Kajal,
Ray Suman,
Maity Suvendu,
Nurjamal Khondekar,
Ghosh Prasanta,
Brahmachari Goutam,
Mukhopadhyay Chhanda
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202004668
Subject(s) - domino , catalysis , environmentally friendly , chemistry , solvent , cycloaddition , indoline , ethanol , combinatorial chemistry , reaction conditions , organic chemistry , ecology , biology
An ultrasound assisted efficient, expeditious and environmentally benign new methodology for direct access to broad ranges of structurally interesting and pharmacologically significant spiropyrido[2,1‐ b ][1,3]oxazino compounds based on three component reactions approach via domino 1,4‐dipolar cycloaddition from easily available starting materials in aq. ethanol medium at room temperature ( 25 – 30 °C ) has been developed. In comparison to that of conventional methods, simple experimental and workup procedure, excellent yields, good functional group tolerance, cleaner reaction profile, use of green solvent are remarkable features of this sonochemical procedure.Furthermore, using of the ultrasound in this methodology leads to the reduction of the reaction times.