Premium
Electrochemical Asymmetric Reduction of Ketoesters Induced by β‐Cyclodextrin Modified by (1S,2S)‐(+)‐1,2‐Diaminocyclohexane
Author(s) -
Wang ZhuoLin,
Zhao YiJun,
Xiong Rui,
Yang LiRong,
Wang Huan,
Lu JiaXing
Publication year - 2021
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202004594
Subject(s) - electrochemistry , yield (engineering) , cyclodextrin , optically active , reduction (mathematics) , chemistry , nuclear chemistry , combinatorial chemistry , materials science , organic chemistry , electrode , mathematics , metallurgy , geometry
Chiral cyclohexanediamine was chemically bonded to β‐cyclodextrin as an inducer to induce the asymmetric reduction of ketoesters under electrochemical conditions. The reaction was carried out in an undivided glass cell to form the optically active products. The whole experiment was carried out under mild conditions without high temperature and high pressure. For the electrochemical asymmetric reduction reaction of ethyl benzoylacetate, 63 % yield and 50 % ee value can be obtained.